MAKER OF OXYCONTIN DELAYS NEW FORM OF DRUG

WASHINGTON - An abuse-resistant form of the powerful but controversial
painkiller OxyContin won't be ready next year as its manufacturer had hoped.

The widely prescribed narcotic painkiller is considered important therapy
for many patients suffering long-term moderate to severe pain from cancer
or other illnesses. When swallowed whole, one tablet provides 12 hours of
pain relief.

But if chewed, inhaled or injected, OxyContin produces a quick, and
potentially lethal, heroin-like high. It has been linked to more than 100
deaths.

Manufacturer Purdue Pharma is trying to create abuse-resistant forms by
adding drugs to block the buzz if OxyContin is taken the wrong way.

One method under consideration is to put the narcotic blocker naloxone in
OxyContin tablets. If the tablets are crushed and injected, naloxone would
enter the bloodstream to block the OxyContin's effects. That wouldn't block
other forms of abuse, but Purdue Pharma had called it an important interim
step that it hoped to begin selling next year. A competing painkiller,
Talwin NX, uses that approach.

But yesterday, Purdue Pharma announced that clinical trials found, among
other problems, that naloxone sometimes blocked pain relief for patients
who took the combination tablets correctly. Purdue Pharma said it won't
seek Food and Drug Administration approval this year and will do further
research to see whether naloxone is worth pursuing.

The company is focusing on another method: turning OxyContin into a capsule
that contains lookalike beads of the painkiller and another narcotic
blocker, naltrexone.