DRUGS 'HALT BRAIN CONNECTIONS'

Taking amphetamines or cocaine could stop cells in key areas of the
brain linking up normally.

This, warn experts, could explain why it is feared that long term use
of the drugs could affect memory or mood.

Rats would be expected to generate new brain "connections" if put in a
stimulating environment - but after being given drugs this did not
happen.

However, experts have warned that results in rat brains may not
correspond exactly to human brains.

Fierce controversy

While there are concerns about the long-term effects of amphetamines
and cocaine on the brain, it remains a controversial area.

While some researchers point to studies which suggest mood problems in
some users, others maintain that firm evidence for a link has still
not emerged.

The latest research was carried out by scientists from the University
of Lethbridge in Canada.

It looked at brain connections in part of the brain called the nucleus
accumbens, and another called the neocortex.

The nucleus accumbens has been linked by other studies to mood, while
the neocortex has some bearing on memory, it is thought.

The rats were all put into a "stimulating" environment - cages with
plenty of ramps, wheels and tunnels.

However, some of them had been repeatedly given either cocaine or
amphetamine a few months earlier.

Animals not given the drugs showed an expected response to their
"exciting" new home - their brains showed signs of increased
connections between brain cells in the key areas.

However, the rats who had been given either drug showed no sign of
these changes.

Long-term

The researchers said: "Perhaps the most important issue raised by the
current study concerns the long-term consequences of drug use for
behaviour and psychological function.

"At least some of the cognitive or behavioural advantages that accrue
with experience may be diminished as a function of prior exposure to
psycho-stimulant drugs.

"We have no direct evidence this is the case, but there is
accumulating evidence that amphetamine and cocaine addicts have
numerous neuropsychological deficits."

A British expert said that rat studies were not necessarily the best
way of predicting what was going on in the human brain.

Professor Dai Stephens, from the University of Sussex, told BBC News
Online: "You have to be rather careful that the doses and treatments
given to the animals are comparable to those taken by human users of
the drugs."

He said that in addition, rats kept in ordinary laboratory cages
before being put into their "enhanced" environment might be considered
understimulated prior to the experiment - and therefore not
necessarily ideal for comparison with humans.

Lesley King-Lewis, chief executive of the UK charity Action on
Addiction said: "This research highlights how little we know about the
detrimental consequences of stimulant drug use.

"It goes some way to explaining the effects on mood and memory we are
already aware of.

"However, it is unclear how applicable research in rats is to humans,
and more work is needed in this area to determine what goes on in
human brains.

"What is apparent from this research is that greater awareness is
needed of the serious neuropsychological effects of stimulant drugs,
to halt the growing use of stimulant drugs in the UK." The study was
published in the journal Proceedings of the National Academy of Sciences.