WHY TEENAGERS SHOULD STEER CLEAR OF CANNABIS

Adolescents' use of marijuana may increase the risk of heroin
addiction later in life, a new study suggests. Researchers say the
work adds to "overwhelming" evidence that people under 21 should not
use marijuana because of the risk of damaging the developing brain.

The idea that smoking cannabis increases the user's chance of going
on to take harder drugs such as heroin is highly contentious. Some
dub cannabis a "gateway" drug, arguing that peer pressure and
exposure to drug dealers will tempt users to escalate their drug use.
Others insist that smoking cannabis is unrelated to further drug use.

Now research in rats suggests that using marijuana reduces future
sensitivity to opioids, which makes people more vulnerable to heroin
addiction later in life. It does so by altering the brain chemistry
of marijuana users, say the researchers.

"Adolescents in particular should never take cannabis - it's far too
risky because the brain areas essential for behaviour and cognitive
functioning are still developing and are very sensitive to drug
exposure," says Jasmin Hurd, who led the study at the Karolinska
Institute in Sweden.

But Hurd acknowledges that most people who use cannabis begin in
their teens. A recent survey reported that as many as 20% of
16-year-olds in the US and Europe had illegally used cannabis in the
previous month.

"Teenage" rats In order to explore how the adolescent use of cannabis
affects later drug use, Hurd and colleagues set up an experiment in
rats aimed to mirror human use as closely as possible.

In the first part of the trial, six "teenage" rats were given a small
dose of THC - the active chemical in cannabis - every three days
between the ages of 28 and 49 days, which is the equivalent of human
ages 12 to 18. The amount of THC given was roughly equivalent to a
human smoking one joint every three days, Hurd explains. A control
group of six rats did not receive THC.

One week after the first part was completed, catheters were inserted
in all 12 of the adult rats and they were able to self-administer
heroin by pushing a lever.

"At first, all the rats behaved the same and began to self-administer
heroin frequently," says Hurd. "But after a while, they stabilised
their daily intake at a certain level. We saw that the ones that had
been on THC as teenagers stabilised their intake at a much higher
level than the others - they appeared to be less sensitive to the
effects of heroin. And this continued throughout their lives."

Hurd says reduced sensitivity to the heroin means the rats take
larger doses, which has been shown to increase the risk of addiction.

Drug memory The researchers then examined specific brain cells in the
rats, including the opioid and cannabinoid receptors. They found that
the rats that had been given THC during adolescence had a
significantly altered opioid system in the area associated with
reward and positive emotions. This is also the area linked to addiction.

"These are very specific changes and they are long-lasting, so the
brain may 'remember' past cannabis experimentation and be vulnerable
to harder drugs later in life," Hurd says.

Neurologist Jim van Os, a cannabis expert at the University of
Maastricht in the Netherlands told New Scientist the research was a
welcome addition to our understanding of how cannabis affects the
adolescent brain.

"The issue of cross-sensitisation of cannabis/opioid receptors has
been a controversial one, but these findings show the drug's damaging
effects on the reward structures of the brain," van Oshe says. "There
is now overwhelming evidence that nobody in the brain's developmental
stage - under the age of 21 - should use cannabis."

The research appears in the online edition of Neuropsychopharmacology.