FINDING NEW PARTY DRUGS LIKE K AND ECSTASY WON'T BE EASY

In the past few months, it's become nearly impossible to buy Ketaset
in New York City's underground drug market. Made by Fort Dodge, an
Iowa-based pharmaceutical firm, Ketaset is a brand of ketamine, a
compound that blocks certain neuroreceptors, causing hallucinations in
high doses and, in lower doses, a fuzzy dissociation--like the warmth
of a couple of Jim Beams. Legally, it's used as an anesthetic.
Illegally, one snorts ketamine because the fuzziness lasts half an
hour and doesn't produce bourbon's four-Advil hangover.

Ketaset's scarcity dates back to August 1999, when the U.S. Drug
Enforcement Administration, acting on preliminary evidence that
ketamine may lead to dependence, subjected its legal purveyors to
strict security rules. But K, as users call it, had already won so
many devotees that traffickers were smuggling off-label brands from
Mexico. Today Manhattan dealers sell a gram of K for $ 80, up 100%
from 1998.

The recent history of K limns a well-established law of recreational
drug use: once users find a substance they like, they will snort or
shoot or drop whatever version is available, whatever the cost. Which
is why you must look to the market to understand the future of drugs
used for anything other than doctor-approved healing. That market can
be divided into three groups: the partyers, who just want to have fun
(and who sometimes become addicts); the shrinks and shamans, who
believe drugs can expand your consciousness; and the scientists, who
suspect that illegal drugs--or their chemical cousins--may have
marketable legal uses. These groups are distinct but tightly linked:
scientific research leads to new drugs, which shamans discover and use
in their quests, which often turn out to be as much fun as spiritual.
The use of drugs in party settings eventually leads to government crackdowns.

But as a rule, the partyers don't pursue the new drugs; they tend to
find a potion and stick with it, sometimes until it kills them.
Today's popular party drugs are derived from ancient medicinal herbs:
marijuana from hemp, cocaine from coca leaf, prescription painkillers
from poppies. It's the shamans who aggressively seek out new
substances. Recent additions to the U.S. market include ayahuasco, a
plant long used in religious ceremonies in Brazil for its
mind-manipulating qualities, and Salvia divinorum, a soft-leaved plant
native to Mexico that is chewed or smoked for hallucinogenic effects.

New compounds do occasionally come from underground drug labs or, like
MDMA (ecstasy), are rediscovered after years of being ignored in
scientific literature. In this world, no one is held in greater esteem
than Alexander Shulgin.

Shulgin is a biochemist who once studied psychedelics for Dow
Chemical. Now 75, Shulgin has synthesized hundreds of compounds in the
smelly lab in the woods behind his California home. He and his wife
Ann, a therapist, have published two books that are the bibles of
underground drug research: PIHKAL (Phenethylamines I Have Known and
Loved) and TIHKAL (Tryptamines I Have Known and Loved). Many of the
drugs that have emerged from underground labs can be traced to
well-thumbed copies of the Shulgins' books.

It was they who helped popularize MDMA--a signal event in the history
of recreational drugs. Ecstasy is easily the biggest advance since
LSD. It changed not only the party world but the shaman world, where
it was used by psychologists who believed it had therapeutic value.
Since MDMA was banned in 1986, scientists have looked for compounds
that have the same effects without damaging neurotransmitters, as MDMA
can. They haven't had much success.

So today's nonmedical drug research tends to focus on new uses for old
substances. That effort is led by Richard Doblin, who runs the
Multidisciplinary Association for Psychedelic Studies out of his
Belmont, Mass., home. Founded the year MDMA was outlawed, the
association uses its $ 530,000 yearly budget to assist scientists who,
with government permission, study the risks and benefits of a wide
variety of nonmedical uses for psychedelic drugs and marijuana. Such
research is highly political, however, and it can take years for a
research protocol to be approved.

The new drugs that appear on the market usually do so after
underground chemists read scientific papers and decide to cook
something up. Scientists studying how cocaine works in the brain, for
example, have developed a version 100 times more powerful. The recipe
is available in academic journals, waiting to be exploited.

But the chemicals needed to synthesize such drugs are tracked by
authorities, a change from the Shulgins' day. And even if the
ingredients were widely available, the scientific expertise is not.
According to David Nichols, a student of Shulgin's who is now a
professor of chemistry at Purdue, "The underground chemist is
typically not going to discover a completely new psychoactive
substance. The kinds of things that are easy to make, by and large,
have been made."