STUDY FINDS POT EASES AIDS PATIENTS' PAIN

WASHINGTON -- AIDS patients suffering from debilitating nerve pain
got as much or more relief by smoking marijuana as they would
typically get from prescription drugs -- and with fewer side effects
-- according to a study conducted under rigorously controlled
conditions with government-grown pot.

In a five-day study performed in a specially ventilated hospital ward
where patients smoked three marijuana cigarettes a day, more than
half the participants tallied significant reductions in pain.

By contrast, less than one-quarter of those who smoked "placebo" pot,
which had its primary psychoactive ingredients removed, reported
benefits, as measured by subjective pain reports and standardized
neurological tests.

The White House belittled the study as "a smoke screen," short on
proof of efficacy and flawed because it did not consider the health
impacts of inhaling smoke.

But other doctors and advocates of marijuana policy reform said the
findings, reported in today's issue of the journal Neurology, offer
powerful evidence that the Drug Enforcement Administration's
classification of cannabis as having "no currently accepted medical
use" is outdated.

"This should be a wake-up call for Congress to hold hearings to
investigate the therapeutic use of cannabis and to encourage more
research," said Barbara Roberts, a former interim associate deputy
director in the White House Office of National Drug Control Policy,
now with Americans for Safe Access, which promotes access to
marijuana for therapies and research.

Countless anecdotal reports have suggested that smoking marijuana can
help relieve the pain, nausea and muscular spasticity that often
accompany cancer, AIDS, multiple sclerosis and other ailments. But
few well-controlled studies have been conducted.

The new study enrolled 50 AIDS patients with severe foot pain caused
by their disease or by the medicines they take.

The team first measured baseline pain, both subjectively (patients
ranked their pain on a scale of 1 to 100) and with two standardized
tests, one involving a small hot iron held to the skin and another
involving hot chili pepper cream.

Then, for five days, patients lit up at 8 a.m., 2 p.m. and 8 p.m.
using a calibrated puff method that calls for inhaling for five
seconds, holding one's breath for 10, then waiting 45 seconds before the next.

The cigarettes were kept frozen and locked in a safe, then thawed and
humidified one day before use. Cigarette butts and other debris were
collected, weighed and returned to the safe to ensure no diversion
for recreational purposes.

The drug, grown on the government's official pot farm in Mississippi,
was about one-quarter the potency of quality street marijuana. The
inactive version was chemically cleansed of cannabinoids, the drug's
main active ingredients.

"It smelled like and looked like" normal marijuana, said study leader
Donald Abrams, a physician at San Francisco General Hospital, where
the smoking ward was located. Like the patients, Abrams was not told
who had the active pot until the study was over.

Thirteen of 25 patients who smoked the regular marijuana achieved
pain reduction of at least 30 percent, compared with six of 25 who
smoked placebo pot. The average pain reduction for the real cannabis
was 34 percent, compared with 17 percent for the placebo.

Opioids and other pills can reduce nerve pain by 20 to 30 percent but
can cause drowsiness and confusion, Abrams said. And many patients
complain that a prescription version of pot's main ingredient in pill
form does not work for them.

That was true for Diana Dodson, 50, who contracted AIDS after a blood
transfusion.

"I have so many layers of pain I can hardly walk," said Dodson, who
was in the new study. Prescription drugs made her feel worse. "But
inhaled cannabis works," she said.

Patients in the study -- all of whom had smoked pot previously --
reported no notable side effects, though the researchers acknowledged
that people unfamiliar with the drug might not fare as well.

Igor Grant, director of the University of California Center for
Medicinal Cannabis Research, which funded the research, said the
study was probably the best-designed U.S. test of marijuana's medical
potential in decades. He called the results "highly believable."

But David Murray, chief scientist at the White House Office of
National Drug Control Policy, called the findings "not particularly
persuasive." The study was relatively small, he said, and it is
likely that those who received the real pot were aware of that,
introducing a bias of expected efficacy.

"We're very much supportive of any effort to ameliorate the suffering
of AIDS patients," Murray said.