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Protein Might Be Linked To Ecstacy Death
Good [+1]Toggle ReplyLink» Purple_Lee replied on Sat Nov 29, 2003 @ 3:45pm
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New York- researchers have identified a protein that might play a role in the sometimes-fatal hypothermia that is caused by overdoses of the club drug ecstasy.

Experiments @ Ohio northern university show mice bred without the protein called UCP-3 heat up less after they have been injected with a doses of ecstasy that kill normal rodents.

The mouse studies are the earliest steps to finding a potential therapy to help humans who develop the irreversible complication after an ecstasy overdose.

When the body over heats enough, skeletal muscle breaks down and organs fail, leading to an agonizing death, said Ted Mills, a U.S. national heart, lung and blood institute researcher and co-author of the study appearing today in the journal Nature. “By isolating the this protein we might be able to see wither, in fact, we can block this hypothermia from occurring,” Mills said.

A resent U.N. report on ecstasy use estimates there has been a least a 70 % increase in worldwide use of recreational drug known also as MDMA or MDA – a chemical cousin of methamphetamine.

Ecstasy typical induces feeling of euphoria, increased energy and sexual arousal. But it also suppresses appetite, thirst and need to sleep, and in high doses can sharply increase body temperature. “This people show up at the emergency room with a fever in the 108- degree (42 C) range,” he said. “ A lot of things happen when the temperature is so high, and one is that muscle cells just start popping open.”

William McCall associated press

Lee
Protein Might Be Linked To Ecstacy Death
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