s of September 2008, there are two versions of HeadOn available in stores: "Extra Strength" and "Migraine". Chemical analysis of the Migraine formulation has shown that the product consists almost entirely of wax. The three active ingredients are iris versicolor 12× (a flower), white bryony 12× (a type of vine), and potassium dichromate 6× (a known carcinogen). The "×" notation indicates that the three chemicals have been diluted to 1 part per trillion, 1 part per trillion, and 1 part per million respectively.[10][11] This amount of dilution is so great that the product has been described as a placebo[12]; with skeptic James Randi calling it a "major medical swindle"[11]. The formula for the Extra Strength version of the product is the same as the Migraine except that it excludes the iris versicolor.

Seymour Diamond, director of the Diamond Headache Clinic in Chicago and the inpatient headache unit at St. Joseph Hospital, was quoted as saying "I see nothing in this product that has any validity whatsoever."[13] Consumer Reports states that no clinical-trial data involving HeadOn have been presented, and that "any apparent efficacy may be the result of the placebo effect."[12]

Correspondence was published with a statement from HeadOn Customer Service that "It works through the nerves."[14]

Originally Posted By V.2.0.MINUS.1

Yes ! Cure your migraine by applying cancerous potassium dichromate right on your forehead. We assure you that once you get liver cancer, your migraine will be the least of your problems !